Does Alpha Lipoic Acid Work?

by D.M. Murdock

Popularized by Dr. Nicholas Perricone, alpha lipoic acid is widely touted as a "wrinkle cure" more effective than skin-care ingredients of the past, such as alpha hydroxy acids. But the anti-aging substance alpha lipoic acid is more than just a skin-care ingredient. Called "possibly the most powerful antioxidant," alpha lipoic acid may increase health and lifespan.

Personal anecdotes reflect that alpha lipoic acid improves the texture and smoothness of skin. Alpha lipoic acid is also used to eliminate the puffiness around the eyes. Another product that works very well to reduce puffiness and dark circles under the eyes is Camocare, which contains extract of chamomile flower. Eye puffiness is a sign of the kidneys being taxed and overworked. Very large bags under the eyes indicates that water has built up around the heart. Along with topical treatments for eye bags and puffiness, it is wise to consume foods and other nutritional products that will increase kidney and heart health. Taking alpha lipoic acid orally may be useful in treating these conditions, as well as any that may be caused by inflammation.

Alpha lipoic acid and diabetes

Over the past several decades, numerous studies worldwide have been done on the beneficial effects of alpha lipoic acid on diabetes and its related permutations, such as kidney disease, neuropathy and blindness. Alpha lipoic acid has been used for years to treat insulin resistance and type 2 diabetes, as well as associated depression and other complications such as neuropathy, a condition caused by diabetes which creates nerve damage that manifests itself as burning, itching, numbness, pain, stinging, tingling and weakness mainly in the hands and feet. Alpha lipoic acid is so effective in lowering blood sugar that it may cause hypoglycemia.

Anti-aging properties

A study by the Journal of Investigative Dermatology concluded that topical alpha lipoic acid is "ineffective as a topical antioxidant for photoprotection of skin." In other words, it does not act as a sunscreen or topically protect against "ultraviolet damage including skin cancer and photoaging chances." Another study done on an antiaging product named Dermavite, which is to be taken orally and which contains "marine proteins, alpha-lipoic-acid, pine bark extract, vitamins and minerals," showed that ALA was effective in reducing wrinkles and other age-related skin problems. Alpha lipoic acid's antiaging benefits are in part likely related to its ability to increase levels of the amino acid glutathione, which also possesses anti-aging properties.

A product called Juvenon, developed by renowned geneticist Dr. Bruce Ames of the University of California at Berkeley, contains alpha lipoic acid and the amino acid L-carnitine, which together make a formidable team against aging and disease. Juvenon is claimed by its creators to "work on the mitochondria to improve cellular health and maintain it over the years," with the result of "healthy aging."

Types and dosages of alpha lipoic acid

There are two types of alpha lipoic acid: the synthetic "S" and the natural "R." It is claimed that only R alpha lipoic acid is effective. The suggested dose for the typical alpha lipoic acid (not R alone) found in stores is 50 to 250 mg. a day, depending on the individual. The suggested dose for R-alpha lipoic acid is 10 to 50 mg. a day For treatment of illnesses such as diabetes or liver disease, a higher dose of alpha lipoic acid such as 600 mg. in two doses daily of 300 mg. each may be necessary. A sustained-release alpha lipoic acid product is in the works.

Side effects of alpha lipoic acid

As is the case with all supplementation, caution is advised in using alpha lipoic acid. Dosages higher than 600 mg. daily are not recommended for long-term use, as there have been no studies of their possible adverse effects. High doses may be overly effective in lowering blood sugar and may lead to hypoglycema. Other reported reactions include sleeplessness, rashes and upset stomach. A high dosage of alpha lipoic acid may cause a strong, sulfur-like smell in the urine, much as does asparagus. This odor appears to be harmless. Alpha lipoic acid is not recommended for use by children or pregnant or nursing women.

Note: The video below was not created by D.M. Murdock/Acharya S and does not necessarily represent her views.